For your location parameter, you can't do that. Parameters only allow a single value. Should you be using a location dimension instead ? (or more precisely - you will have to use a location dimension if you want a multi-select option)
For your time parameter you will need 3 parameters - one for today, last week and custom, then another one for the start date and another one for the end date.
So you'll have to redesign some parts of your database &/or workbook to accommodate this.
There is a blog on multi select parameter , please go through it
Do hit the CORRECT and HELPFUL button if it really helps you so that it can help others as well
Thank you chris