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You can plot them on a map and create custom territories. This way you can select multiple fields.
There are probably several ways - as you say if there are hundreds of regions one way is to create a 2 column file with the "Actual" region in one column and the "New region" in the other - then upload the file and join it with the existing data - at that point you need to make New Region a geo dimension created from the old region
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