Do you need to expose this as a quick filter so the end-user can dynamically change what is excluded? Or do you simply always want to exclude a certain set of values?
If the later, then the solution is relatively simple. Create a calculated field called [Email Filter] with code like this:
Then place it on the Filters shelf and select "True" so those get filtered out. (You may want to adjust the code to take string case into account as needed).
Hopefully, that gets you what you want. If not, I'd be happy to think through some alternatives.