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One tip would be to have one master workbook that you make all of the edits on. And then you could replace the data source for each region and save a copy of the workbook. It would still mean multiple copies of the workbook, but at the very least you won't have to make the same edits in each workbook. For directions, see Replace Data Sources - Tableau
Can you aggregate your extract? For example if you only need daily totals, you could roll the data up to the day level. This method would allow you to still get the correct daily totals, but could decrease the number of rows in the extract. See the "Determine how much data to extract" section of Extract Your Data - Tableau
Hope this helps!