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I assume you've tried a "Save As..." and it's not working either. The only other thing I can think of is that there might be a clipboard data source that is being saved as a temporary file, but the temp directory no longer exists. Can you post a screenshot of your data sources?
After some additional tests, it turns out that the problem is related to the extract the workbook is connected to on the tableau server.
Thank you so much for responding!
Glad you got it to work!