If you are trying to get a count distinct of program and work_package, then you could concatenate those fields in a calculation and then do a count distinct of that field.
[Program] + [Work_Package]
Place that calculation in the view and change it to a measure (COUNTD).
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Joshua's suggestion works very well when you are not already partitioning by the manager. However, for the example you gave, you should be able to do it without any calculated fields (as long as your data is stored as an extract) by placing Manager on the Rows shelf and then just doing a count distinct on the Work Package field.
Hope this helps!