Can you attach your workbook, or a fake workbook with mocked up data, so I can take a look?
I'm not sure if there is a straightforward way to get to it using Quick Filters.
There may be a possibility to use control-click action-filters
as shown by Jonathan Drummey:
For your example, created four action filters: include region, exclude region, include category, exclude category.
Please see workbook v10.3 attached in the Forum Thread:
315984incexc_v10.3.twbx 2.4 MB