One possible solution for creating a line graph where each line is affected by separate filters is to duplicate the data source and then pull one measure from each data source. Filters made from the same fields in the separate data sources will only affect the measure from that data source as long as the data sources are only linked on the x-axis value, in this case [Order Date].
I have attached an example workbook where two [Sales] lines are filtered by separate [Region] filters. Directions for the view are also in the workbook.
I hope this answers your question!
Filter lines separately.twbx 1.2 MB