The performance problem is almost certainly because you have so many quick filters. Build a simpler dashboard and allow users to drill down for more info into other worksheets dashboards.
Perhaps more importantly, setting 12 out of 15 to "only relevant values" can be a real performance killer. Just setting 10 of those 12 to "all values in database" should improve performance dramatically. However, 15 filters is a LOT and probably not necessary.